Clinical trials to compare two treatments

Is it appropriate to compare the results from two clinical trials with one drug in common?

factor to be considered when determining patient suitability for transcatheter implantation. Variables such as calcium quantity and distribution, the width of the sinuses of Valsalva, outflow tract diameter or computed tomography-measured annulus diameter (maximum annulus diameter was 23.9 mm) must also be analyzed. Since percutaneous implantation techniques began to be used for aortic valves, ...

Clinical trials, devices, unproven treatments, and clinical equipoise.

Combining Global and Marginal Tests to Compare Two Treatments on Multiple Endpoints

We consider the problem of comparing two treatments on multiple endpoints where the goal is to identify the endpoints that have treatment effects, while controlling the familywise error rate. Two current approaches for this are (i) applying a global test within a closed testing procedure, and (ii) adjusting individual endpoint p-values for multiplicity. We propose combining the two current meth...

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

Evidence Based Medicine: Clinical Trials

Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...